Doctor's Visit, Cimetidine vs. the Immune System

I've been trying to get around to posting since Monday, but it seems like the trip up to L.A. is taking more and more out of me lately.
I seem to spend days recovering my energy.
Anyhow, it went wonderfully. My doctor was a sweetheart, it didn't turn out as expensive as I'd feared, and I came away with a new treatment option.

Unfortunately, the trip up there took a bit out of me as well, plus with brain fog rising back up lately, I just couldn't concentrate on some very interesting info the doctor shared with me on what he thought of XMRV and some tests being done. I remember the info, I just can't seem to make it fit together, so I figure if I come across something related later on, it will probably make sense.

As for the "new" treatment, he suggested I try, of all things, Tagamet, aka cimetidine. Normally used as an antacid, it turns out cimetidine has been used off-label to modulate the immune system, specifically in the treatment of viruses that cause warts. The key word of course, being "viruses". (I can hardly believe I'd never heard this one before!)
But yes, I did some research, and my findings were quite interesting.

So my plan is to get back on the oxymatrine/herbal supplement I was taking (as I've realized that the brain fog began to get worse about the time I stopped it, and with a little prodding from the doc, that the aches & pains & fatigue and feverishness increased around the same time) keep taking the lamivudine (anti-viral commonly used in HIV & Hepatitis which has shown some effectiveness against strains of the Coxsackie B virus) and start the cimetidine. And once again, I will wait. And see.
And I will try and do it patiently. :)

Here are some links regarding Cimetidine and CFS/Viruses/Immune System Function. Also, I was quite interested to see that it has also been used as a treatment for such illnesses as PCOS (Polycystic Ovary Syndrome) Fibroids, Endometriosis, and other "estrogen dominant" disorders, as well as for Interstitial Cystitis (per Wikipedia, source cited). I'm curious to see as well, if it helps control my allergies (being a histamine blocker) and helps my stomach at all. (I also read a tidbit somewhere about it being good to take probiotics with an acid blocking medication for better effectiveness.) Very interesting stuff...


Tagamet on Wikipedia (before you scoff, it has plenty of citations)


Tagamet and CFS

More info on Cimetidine
AboutMeCFS Forum - Tagamet

A New Fibromyalgia Remedy: Antiviral Drugs - US News and World Report

Though I feel this is a bit oversimplified, I think it's an interesting article, especially the part about the allergies!

A New Fibromyalgia Remedy: Antiviral Drugs - US News and World Report

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Milnacipran Shows Success in Treating FM?

Milnacipran is the name of a new drug being tested for Fibromyalgia. It is actually an anti-depressant, of the SSNRI (Selective Seretonin Norepinephrine Reuptake Inhibitor) type that has been available in Austria for a decade.

According to the study at the link below, it has shown success in treating symptoms of FM, as well as Lupus.

After reading the study however, it occurs to me that this is just another Cymbalta. This may sound a little jaded, but it seems to me, that the drug companies are just looking for medications to throw at FM,so that they can make money off the millions of people who suffer from it. This isn't a cure...it may help some,especially those suffering with depression as well as FM, but not all, just as Cymbalta did. (Note that Cymbalta was recently NOT approved for treating FM in Europe.) All it does is tinker with a couple of neurotransmitters, and although these have been found to be off in FM, they are not the cause, just two more of the myriad of symptoms.
Sure, it might help people with FM, improving quality of life by improving mood and outlook, and having a slight effect on pain, but we have plenty of drugs like that already; we don't call THOSE "FM Drugs"... It just makes me wonder if this title should be given to any drug that doesn't help everyone, or nearly everyone who suffers from this disease. (Insulin wouldn't be considered a diabetes drug if it only helped some people who had diabetes, right?) To be precise, it does say "for the Management of Fibromyalgia" but no doubt it will be touted as a drug for treating FM. I can see the commercials now...
If it helps some people, that's great, but I kind of wish they would focus more on finding the cause, or at the very least a surefire diagnostic test.

Just my two cents.

Here's a link to the study: Positive-Results-of-Phase-III-Study-of-Milnacipran-for-the-Management-of-Fibromyalgia-3573-1/

*Correction: I actually got the Lupus link from this site, under Experimental Uses:http://en.wikipedia.org/wiki/Milnacipran